Dong Hyun Jo

The paper shows that bystander base editing with ABE8e impairs visual function restoration in LCA model mice by causing structural and functional disruptions in RPE65.

This study corrects a SSBP1 mutation using adenine base editors, improving mitochondrial function but with trade-offs between editing efficacy and off-target risks.

This study uses adenine base editing to correct a nonsense mutation in a mouse model of LCA, improving visual function.

CRISPR-pass uses adenine base editors to bypass nonsense mutations in patient-derived fibroblasts, showing potential for treating genetic disorders.