Vlad I. Nicolaescu

This study develops a polymer-lipid hybrid nanoparticle (PLNP) to enhance mRNA delivery and T cell immunity, showing improved antigen-specific T cell responses and protection against viral variants and cancer.

This paper introduces an antibody language model (AbLM) to accelerate IgG screening and design for broad-spectrum antiviral therapy, achieving higher precision in predicting variant-resistant antibodies.

The paper shows that Tipiracil inhibits SARS-CoV-2 Nsp15 by binding to its uridine site, supporting its potential as a drug scaffold for antiviral development.

This paper reports structural and biochemical studies of SARS-CoV-2 papain-like protease and its complexes with inhibitors, showing their ability to inhibit enzyme activity and viral replication.