NeurosciencebioRxivPreprint
Negative allosteric modulation of cannabinoid CB1 receptor signaling suppresses opioid-mediated tolerance and withdrawal without blocking opioid antinociception
Vishakh Iyer, Shahin A. Saberi, Romario Pacheco…·Andrea G. Hohmann
This study shows that the CB1 receptor NAM GAT358 reduces opioid tolerance and withdrawal without impairing analgesia in mice.
2 citations