Edward M. Callaway

This paper identifies a disinhibitory basal forebrain to cortex projection that regulates sustained attention by modulating cortical gain based on motivational salience.

The paper shows that corticostriatal projections to D1- and D2-SPNs are asymmetrically overlapping and that pathway-specific subcircuits control distinct behaviors.

The paper maps cortico-thalamo-cortical circuits in mice, revealing complementary rules for driver and modulator connections in higher visual areas.

The paper investigates how direction and orientation selectivity in mouse V1 layer 4 neurons is influenced by retinal inputs through parallel pathways.

This study develops high-resolution methods to identify thin layers in macaque V1 using Neuropixels probes by analyzing electrical signals and spike waveforms.

The paper quantifies the efficiency of retrograde monosynaptic rabies virus tracing in mouse primary visual cortex, finding about 40% of first-order presynaptic excitatory inputs are labeled.

The paper uses single nucleus RNA-sequencing to analyze human cortical areas, revealing cell type proportions and gene expression patterns that correlate with functional connectivity and areal specialization.

The paper links single-cell epigenomes and projection patterns of 33,034 mouse neurons to identify transcriptomic and epigenomic properties of projection cell types.

The paper analyzes gene regulatory programs in the neocortex of rodents and primates using single-cell multiomics, finding rapid evolution of cell type-specific gene expression and TE-driven cCREs.

The paper shows that cone-opponent signals in V1 are organized into functional domains that generate color appearance through spatially ordered neural circuits.

The paper generates a multimodal cell census and atlas of the mammalian primary motor cortex, revealing a unified molecular genetic landscape and cross-species taxonomy of cell types.

The paper constructs a DNA methylation atlas of the mouse brain at single-cell resolution, revealing epigenetic diversity and spatial organization of neuronal subtypes.

The paper links epigenomic properties of cortical projection neurons to their anatomical and projection patterns using single-nucleus DNA methylation sequencing in mice.

The paper shows that layer 5 corticothalamic projections drive visual responses in the pulvinar, while layer 6 provides baseline excitation, with subcortical inputs also contributing.

This study identifies monosynaptic projections to excitatory and inhibitory preBotzinger Complex neurons from brainstem and suprapontine regions using rabies tracing.

This study investigates how corticothalamic pathways modulate first- and higher-order visual thalamic nuclei in awake mice through optogenetic stimulation and electrophysiology, revealing context-dependent and dynamic effects.

The paper identifies three subregions in the mouse lateral posterior nucleus that form corticothalamic loops biased towards ventral or dorsal visual streams and reveal distinct input sources driving their activity.