Jeremy F. Reiter

This study shows that primary cilia in cardiac fibroblasts promote fibrosis and impair heart function after myocardial infarction by amplifying fibrotic signaling.

This study classifies ADPKD-causing missense variants in polycystin-1 into two categories based on their effects on cell surface localization or ion channel function and suggests small-molecule therapies.

The paper shows that cilia and BBS4 are essential for postnatal pituitary development through Hedgehog signaling.

This study develops an iPSC-based platform to functionally analyze genetic variants in lung disease, demonstrating its application in diagnosing a variant of uncertain significance in primary ciliary dyskinesia.

This study identifies RSG1/CPLANE2 as a causative gene for human ciliopathy and shows its role in ciliary transition zone assembly.

The paper shows that SMO inhibits PKA at cilia to activate the HH signaling pathway, dependent on GRK2/3.

This study shows that multicilia in the choroid plexus transduce non-canonical Shh signaling to regulate CSF production by repressing Aqp1 and Atp1a2 expression.

This paper identifies genetic variants in tubule epithelial regulatory elements that explain most heritable differences in human kidney function using GWAS, scATAC-seq, and functional assays.

The paper investigates how physiological conditions like feeding, obesity, and circadian rhythm affect ciliary GPCR localization and cilia dynamics in the brain using MCHR1 and NPY2R as models.

The paper identifies MYCL and HEY1 as opposing transcription factors mediating Notch-dependent airway stem cell fate decisions through single-cell RNA sequencing and CUT&RUN.

This study shows that Atxn10 is essential for embryonic heart development and adult kidney and pancreas function, with loss leading to lethality and epithelial to mesenchymal transition.

The paper shows that ciliary Hedgehog signaling is essential for cell survival in the facial midline, and its disruption causes craniofacial defects in mouse models of ciliopathies.

This study shows that MRAP2 is essential for MC4R's localization to primary cilia and its role in regulating energy homeostasis and body weight.

This study shows that ciliary signaling patterns smooth muscle, which generates mechanical forces that activate YAP to drive longitudinal growth in the developing esophagus and small intestine.

This paper identifies DYRK2 as a ciliary kinase involved in Hedgehog signal transduction, showing its role in ciliary morphology and skeletal development.

This study shows that primary cilia regulate direct versus indirect neurogenesis in the developing cerebral cortex, with Inpp5e mutations causing increased direct neurogenesis and layer V neuron overproduction.