Chia‐Feng Tsai

This study identifies MYST acetyltransferases as therapeutic targets in SETBP1-mutant leukemia, showing that MYST inhibitors reduce target gene expression and improve survival in mouse models.

The paper presents a long-read RNA-seq atlas of microglia isoforms, identifying novel isoforms and their associations with genetic risk loci in Alzheimer's and Parkinson's disease.

This paper introduces a method for label-free single voxel proteomics using wcSOP, enabling spatial resolution of protein expression in tissue samples.

The paper compares cerebrospinal fluid proteomes of ME/CFS patients with and without fibromyalgia, finding no significant differences, suggesting they may not be distinct conditions.

This paper introduces TIFF, a method enhancing single-cell proteomics sensitivity and accuracy by filtering background ions and using 3D MS1 feature matching, achieving deep proteome analysis in single cells.

The paper introduces a motif-centric phosphoproteomics approach to quantify phosphorylation pathways using in vitro kinase reactions and isobaric labeling, demonstrating selective quantification of over 7,000 tyrosine phosphorylation sites.

This paper introduces a nested nanowell chip to improve single-cell proteomics throughput and robustness, demonstrating the ability to quantify ~1500 proteins from ~100 cells with low abundance variation.