Author

Jorge E. Galán

Yale UniversityORCID 0000-0002-6531-0355Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Marı́a Lara-TejeroiD· 2 shared Eduardo SotoiD· 1 shared Emily Z. GuoiD· 1 shared Leopoldo F. M. MachadoiD· 1 shared Steven Z. ChouiD· 1 shared Tingting Wang· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 6 mutual co-author links

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2 shared papersMicrobiology

Marı́a Lara-TejeroORCID

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3 papers

Recent·Most cited

MicrobiologymBioPeer-reviewedFeb 27, 2026

Interplay between SpaO variants shapes the architecture of the Salmonella type III secretion sorting platform

Eduardo Soto, Tingting Wang, Jorge E. Galán, Marı́a Lara-Tejero

This study investigates the role of SpaO variants in Salmonella's type III secretion system, showing SpaOshort is a structural component of the sorting platform.

4 citationstop 1%

bacteria (other)experimental assay

𝕏 PostBluesky

MicrobiologymBioPeer-reviewedApr 4, 2024

Loss of function of metabolic traits in typhoidal Salmonella without apparent genome degradation

Leopoldo F. M. Machado, Jorge E. Galán

This study identifies single amino acid substitutions in S. Typhi that inactivate metabolic pathways, explaining its metabolic limitations compared to S. Paratyphi A.

3 citations

humanDNA methylation

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MicrobiologybioRxivPreprintDec 21, 2023

Cryo-EM structure of the bacterial effector protein SipA bound to F-actin reveals a unique mechanism for filament stabilization

Emily Z. Guo, Steven Z. Chou, María Lara-Tejero, Jorge E. Galán

The paper reports the cryo-EM structure of SipA bound to F-actin, revealing how it stabilizes actin filaments and shows this activity is separate from its role in inflammation.

2 citations

bacteria (other)cryo-EM

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