Kimberly E. Roche

This study shows that combining radiotherapy with CpG, a TLR9 agonist, enhances tumor response in a mouse sarcoma model by boosting CD8 T cell activity.

The paper develops a microbiome-based age predictor for wild baboons using 13,563 gut microbial profiles and finds that microbiome age reflects current social and environmental conditions but not developmental milestones or lifespan.

This study evaluates the accuracy of differential abundance analysis using renormalized relative count data compared to absolute abundances, finding high consistency but potential for increased false positives under widespread abundance changes.

The paper evaluates zero-handling models in genomic and microbiome data, showing significant disagreement in identifying differentially expressed sequences and finding simple count models sufficient across processes.