Narayanaswamy Srinivasan

The paper compares structural networks of remote homologous protein domains from different architectures to assess how domain combinations influence structural and evolutionary changes.

This study identifies SIRT2 as a regulator of stress-induced skeletal muscle atrophy by inhibiting glucocorticoid receptor signaling, showing protective effects in mice.

This study identifies secondary shell hotspots in protein-protein complexes, showing they are evolutionarily conserved and crucial for stability and activity.

This study investigates how phosphorylation affects protein structure, dynamics, and surface accessibility, revealing both local and distant changes in protein behavior.

This study uses computational methods to analyze how RbpA affects RNA polymerase assembly dynamics in Mycobacterium tuberculosis, identifying structural changes and potential ligands for drug development.

The paper evaluates two methods for identifying interface residues in protein-protein complexes and shows they identify different residues with distinct properties and roles.

The paper analyzes the structural and energetic effects of the D614G substitution in SARS-CoV-2 spike protein, finding it enhances thermodynamic stability and may increase infectivity.

The paper introduces kPred, a knowledge-based method for predicting protein backbone conformations using structural prototypes, achieving mean Q16 accuracies between 40.8% and 66.3%.