Pharmacology & ToxicologyACS Pharmacology & Translational SciencePeer-reviewed
Tenofovir Activation is Diminished in the Brain and Liver of Creatine Kinase Brain-Type Knockout Mice
Colten D. Eberhard, Eric P. Mosher, Namandjé N. Bumpus, Benjamin C. Orsburn
This paper shows that CKB knockout mice have reduced tenofovir activation in brain and liver, with specific mutations impairing CKB's ability to generate the active metabolite TFV-DP.
3 citations