Author

Alexandra Mihuț

HUN-REN Szegedi Biológiai KutatóközpontORCID 0000-0002-6577-4440Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Gyula TiminszkyiD· 2 shared Roberta Fajka‐BojaiD· 2 shared Abhishek Bharadwaj SharmaiD· 1 shared Andrew James BowmaniD· 1 shared Anna Georgina KopasziD· 1 shared Dávid SzütsiD· 1 shared Debanjan GhoshiD· 1 shared Eva Pinto JuradoiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

Gyula TiminszkyORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintOct 22, 2025

Sustained poly(ADP-ribosyl)ation limits RPA loading and attenuates ATR-CHK1 signaling upon replication fork collapse

Alexandra Mihuț, Debanjan Ghosh, Dávid Szüts…·Gyula Timinszky

This study shows that sustained PARylation reduces RPA loading and dampens ATR-CHK1 signaling during replication fork collapse, linking PARP activity to checkpoint control.

DOI 10.1101/2025.10.22.683893

experimental assaychromatin & epigenetic regulation

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Cell BiologyNucleic Acids ResearchPeer-reviewedJun 3, 2024

The loss of DNA polymerase epsilon accessory subunits POLE3-POLE4 leads to BRCA1-independent PARP inhibitor sensitivity

Hasan Mamar, Roberta Fajka‐Boja, Mónika Mórocz…·Gyula Timinszky

This study shows that loss of POLE4 leads to PARP inhibitor sensitivity independent of BRCA1, through replication stress and DNA-PK signaling changes.

13 citations

humanDNA methylation

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