Paclitaxel-induced mitotic arrest results in a convergence of apoptotic dependencies that can be safely exploited by BCL-XL degradation to overcome cancer chemoresistance
Xingping Qin, Adam G. Presser, Lissah Johnson…·Kristopher A. Sarosiek
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Broad InstituteORCID 0000-0002-6578-3216Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
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Xingping Qin, Adam G. Presser, Lissah Johnson…·Kristopher A. Sarosiek
Ruolin Liu, Eugenia Roberts, Heather Anne Parsons…·Viktor A. Adalsteinsson
DirectHRD is a whole-genome sequencing-based classifier that improves HRD detection sensitivity in low tumor fraction samples.
Verónica Rendo, Michaël Schubert, Nicholas Khuu…·Floris Foijer
The paper identifies ARGOS genes, which are amplified in cancer, have low expression relative to copy number, and are toxic when overexpressed, and validates several as pan-cancer targets.
Michal Slyper, Caroline B. M. Porter, Orr Ashenberg…·Aviv Regev
The paper develops a toolbox for scRNA-Seq and snRNA-Seq of fresh and frozen human tumors, testing it across eight tumor types and optimizing protocols for different tissue characteristics.