Abdelmoneim Eshra

The paper measures the Ca2+ sensitivity of Syt1-triggered release in neocortical synapses and finds it has high affinity and cooperativity.

This study shows ketamine increases presynaptic glutamate release in cerebellar synapses by enhancing calcium influx and vesicle readiness, suggesting a direct presynaptic mechanism for its antidepressant effects.

The paper investigates Ca2+-dependence of synaptic vesicle recruitment, priming, and fusion at cerebellar mossy fiber synapses, revealing distinct Ca2+ sensors for each step.

The paper identifies biophysical gradients in cerebellar granule cells that enable Fourier-like transformation of mossy fiber inputs and enhance spike-timing precision.

This study shows HCN channels modulate action potential velocity and fidelity in central axons through cAMP and neuromodulators, with implications for energy consumption and temporal delays.