Cancer BiologyInternational Journal of Molecular SciencesPeer-reviewed
Assembly of mTORC3 involves binding of ETV7 to two separate sequences in the mTOR kinase domain.
Jun Zhan, Frank C. Harwood, Sara ten Have…·Gerard C. Grosveld
This study identifies mTORC3, a rapamycin-resistant mTOR complex that requires ETV7 binding, and shows that specific mTOR and ETV7 domains mediate this interaction, with implications for cancer therapy.
9 citations