Angus I. Lamond

CysNet infers cysteine redox proteoforms from mass spectrometry data, resolving oxiform states and quantifying their abundance in human stem cells.

This paper develops a workflow to identify proline hydroxylation sites using HILIC and LC-MS, finding 4,993 and 3,247 sites in HEK293 and RCC4 cells, respectively.

The paper shows DNA methylation maintenance is linked to lagging-strand replication and TE control in mouse cells, with TE integration preferentially occurring on the lagging strand.

ReCap enables redox proteomics by preserving redox states and scaling oxidation to protein copy numbers, revealing sparse and quantitatively concentrated cysteine oxidation signals.

This study shows DNA replication enables chromatin changes during human iPSC differentiation by allowing protein access to nascent DNA, with H3K9 methylation and proteins like ERH and SETDB1 playing key roles.

This study identifies the differential roles of SRSF1's RNA recognition motifs in protein interactions using SILAC proteomics.

This study identifies the CaMKII-RNMT axis as a mechanism controlling activity-dependent RNA dynamics and neuronal morphogenesis through phosphorylation and degradation of RNMT.

This study identifies PHD1-dependent hydroxylation of RepoMan at P604, showing it regulates mitotic progression by modulating PP2A interaction and H3T3 phosphorylation.

This study compares the proteomes of human induced pluripotent stem cells (hiPSCs) and embryonic stem cells (hESCs), finding quantitative differences in protein expression affecting growth, metabolism, and secreted factors.

This study identifies mTORC3, a rapamycin-resistant mTOR complex that requires ETV7 binding, and shows that specific mTOR and ETV7 domains mediate this interaction, with implications for cancer therapy.

This study identifies FAM111A as a regulator of DNA replication origin activation and shows its interaction with FAM111B and HMCES, with implications for disease when its peptidase domain is intact.

This study shows that transcription restart after DNA replication promotes chromatin reestablishment but is also linked to genotoxic stress.

The paper characterizes proteome variation across 202 human iPSC lines, identifies 700 pQTLs, and links pQTLs to disease-associated GWAS variants.

The paper shows that erosion of X chromosome inactivation in human iPSCs leads to increased protein expression from X-linked and autosomal genes, altering protein-RNA correlations and increasing protein content.

The paper uses single-cell RNA-seq of differentiating iPS cells from 125 donors to identify expression quantitative trait loci influencing gene expression during endoderm differentiation.

The paper identifies CG2941 as a Gemin4 ortholog in Drosophila melanogaster and shows its essential role in organismal viability.

The paper evaluates the impact of integrating multiple TMT batches in proteomic analysis and proposes solutions to reduce missing values, false positives, and inter-batch accuracy issues.

The paper presents a proteomic analysis of 217 HipSci iPSC lines, identifying >16,000 protein groups and their roles in iPSC biology.

In suspended human keratinocytes, five induced phosphatases dampen ERK to drive differentiation commitment, opposed by DUSP10, in a time-rewired network that renders commitment an unstable switch.

This study identifies the Aquarius/EMB-4 helicase as essential for initiating small RNA-induced co-transcriptional gene silencing in C. elegans by facilitating HRDE-1 complex engagement with nascent transcripts.

This study analyzes 522 human iPSCs to identify genetic sources of phenotypic variation, finding 5-25% of variation in traits like differentiation capacity is due to individual differences.

This study shows PHD2 hydroxylates CENP-N, regulating its localization and interaction with CENP-L, which affects CENP-A stability at centromeres.