Author

Manickam Gurusaran

Wellcome Centre for Cell BiologyORCID 0000-0002-6603-3118Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:structural biology· 2 Organism:Arabidopsis· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Owen Richard DaviesiD· 2 shared Amy E. MilburniD· 1 shared Carmen Espejo-SerranoiD· 1 shared Dhananjaya S. KulkarniiD· 1 shared Hiroki ShibuyaiD· 1 shared Ian R. AdamsiD· 1 shared James M. DunceiD· 1 shared Jingjing ZhangiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

Owen Richard DaviesORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintMay 10, 2026

Molecular architecture of meiotic pro-crossover factor HEI10 reveals coupling of higher-order assembly and ubiquitin chain formation

Amy E. Milburn, Dhananjaya S. Kulkarni, Carmen Espejo-Serrano…·Owen Richard Davies

This study determines the molecular structure and function of HEI10, revealing its role in ubiquitin chain formation during meiosis.

1 citation

humanArabidopsis

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BiochemistryNature CommunicationsPeer-reviewedAug 2, 2024

MEILB2-BRME1 forms a V-shaped DNA clamp upon BRCA2-binding in meiotic recombination

Manickam Gurusaran, Jingjing Zhang, Kexin Zhang…·Owen Richard Davies

The paper reports the crystal structure of MEILB2-BRME1 complex and shows how BRCA2 binding causes it to form a V-shaped DNA clamp to facilitate meiotic recombination.

3 citations

structural biologyexperimental assay

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