Carmen Espejo-Serrano

This study identifies RNF25 as an E3 ubiquitin ligase that maintains genome integrity by modulating DNA replication, transcription, and translation through ubiquitin-mediated clearance of key proteins.

This study determines the molecular structure and function of HEI10, revealing its role in ubiquitin chain formation during meiosis.

PLAMseq identifies genomic loci and protein interactors in a single workflow, validated for RNA polymerase II and CTCF, and applied to study histone H1 SUMOylation.

This study shows that activating LRH-1/NR5A2 reduces inflammation in T1D by altering immune cell metabolism and improves human islet function in mice.

This study compares the proteomes of human induced pluripotent stem cells (hiPSCs) and embryonic stem cells (hESCs), finding quantitative differences in protein expression affecting growth, metabolism, and secreted factors.

The paper identifies PCNA as a substrate of BRCA1/BARD1 ubiquitin E3 activity, showing it promotes replication fork stability and continuous DNA synthesis without requiring Homologous Recomberation or Olaparib resistance.

The paper investigates the role of imprinted XCI in polar trophoblast cells and shows that the Rlim-Rex1 axis is essential for maintaining their fate and preventing early lethality in female mice.

This paper identifies a novel RLIM variant causing severe Tonne-Kalscheuer syndrome by disrupting protein stability and function.