Michael Sixt

This study shows that substrate disorder promotes single-cell cancer invasion, comparable to cadherin loss, by altering invasion dynamics through spatial heterogeneity.

This study identifies a conserved VPS34-PIKfyve-TRPML1-Myosin II axis that controls the speed of amoeboid cell migration by regulating retrograde actin flow through Ca2+ efflux.

This study shows Asgard archaea use dynamic actin-based protrusions for crawling motility, similar to eukaryotic cells, and this process is inhibited by actin inhibitors.

This study introduces a theoretical framework for self-organized chemotaxis in heterogeneous cell populations and validates it with in vitro experiments on immune cell co-migration.

This study shows how immune cells adjust their actin dynamics in dense environments to navigate through tissue by shifting their nucleus position and coordinating protrusive forces.

This study models branched-cell chemotaxis in complex environments and finds that slow cells are more accurate in following weak chemoattractant signals, while neutrophils behave as fast cells compromising accuracy.

This study shows that RNA editing of FLNA in myeloid cells reduces intestinal inflammation and protects against colitis in mice and humans.

This paper develops a 3D-ECM platform to visualize native extracellular matrix structures using cryo-FIBSEM and cryo-ET, revealing new insights into ECM composition and organization.

The paper introduces an integrated modelling approach to analyze spatial imaging data, showing it can reliably estimate parameters even with noise and provide biological insights.