Author

Michael S. Overton

University of California San DiegoORCID 0000-0002-6637-6962Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Organism:yeast· 2 Approach:experimental assay· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Sergey KryazhimskiyiD· 2 shared Alena MartsuliD· 1 shared Justin R. MeyeriD· 1 shared Krypton CarolinoiD· 1 shared Omar S. AkbariiD· 1 shared Sean E. Guy· 1 shared Xingsen CheniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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2 shared papersEvolutionary Biology

Sergey KryazhimskiyORCID

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2 papers

Recent·Most cited

Evolutionary BiologyG3 Genes Genomes GeneticsPeer-reviewedFeb 18, 2026

Experimental Test of Evolutionary Safety of a CRISPR-Cas9 Gene-Drive Element

Michael S. Overton, Sean E. Guy, Xingsen Chen…·Sergey Kryazhimskiy

The paper tests the evolutionary safety of CRISPR-Cas9 gene drives in yeast by measuring their impact on mutation rates and loss-of-heterozygosity, finding minimal effects.

5 citations

yeastexperimental assay

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Evolutionary BiologyGeneticsPeer-reviewedDec 22, 2025

Improved Genotype Inference Reveals Cis- and Trans-Driven Variation in the Loss-of-Heterozygosity Rates in Yeast

Michael S. Overton, Sergey Kryazhimskiy

The paper improves genotype inference in yeast to reveal that LOH rates vary due to trans and cis factors, challenging previous findings.

2 citations

yeastwhole-genome sequencing

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