Justin R. Meyer

The paper tests the evolutionary safety of CRISPR-Cas9 gene drives in yeast by measuring their impact on mutation rates and loss-of-heterozygosity, finding minimal effects.

The paper demonstrates that experimental phage evolution can expand the host range of phages to kill multidrug-resistant and extensively-drug-resistant Klebsiella pneumoniae isolates.

The paper studies a phage lacking PhuZ, showing it replicates efficiently without this protein, highlighting variation in nucleus-based replication pathways.

This paper develops methods to detect and optimize sampling for multiphasic virus decay, applying them to show that 94% of phage ΦD9 decays 16-fold faster than the remaining population.

The paper shows that cryptic host phenotypic heterogeneity drives diversification of bacteriophage λ through receptor expression oscillations and negative frequency-dependent selection.

The paper shows a mobile intron in bacteriophage ΦPA3 uses its homing endonuclease to interfere with co-infecting phage ΦKZ, providing a competitive reproductive advantage.

This study shows how fitness landscapes change during adaptation, enabling speciation by opening new adaptive pathways in bacteriophage lambda.

This study shows that bacteriophage Φ21 evolves new host receptor usage through destabilizing mutations that create non-genetic phenotypic heterogeneity in viral particles.

The paper uses machine learning to predict phage-bacteria interactions from genome sequences and phenotypic data, achieving 86% accuracy in predicting interactions and reducing error by 40%.