Author

Behnoush Seifinoferest

University of California, MercedORCID 0000-0002-6671-9654Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:protein design· 2 Assay:protein structure· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Assay:protein sequence· 1

Frequent Co-Authors

Michael C. ThompsoniD· 2 shared Roberto A. ChicaiD· 2 shared Amy E. HuttoniD· 1 shared Anthony P. GreeniD· 1 shared J. D. M. MilleriD· 1 shared Johann A Wehrstedt· 1 shared Jordan BerreuriD· 1 shared Joshua M. RodrigueziD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Michael C. ThompsonORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintSep 14, 2026

Multistate Enzyme Design Enables Efficient and Stereoselective Multistep Catalysis

N. T. Hang Pham, Rui Guo, Rosalinda P Garcia Jimenez…·Roberto A. Chica

This paper introduces multistate enzyme design to optimize active sites across reaction coordinates, achieving higher catalytic efficiency and enantioselectivity than single-state designs.

DOI 10.64898/2026.09.11.750617

protein structureprotein sequence

𝕏 PostBluesky

BiochemistryJournal of the American Chemical SocietyPeer-reviewedMar 27, 2024

Design of efficient artificial enzymes using crystallographically-enhanced conformational sampling

Rojo V. Rakotoharisoa, Behnoush Seifinoferest, Niayesh Zarifi…·Roberto A. Chica

This paper designs artificial enzymes with high catalytic efficiency using crystallography-enhanced computational methods, achieving improvements comparable to directed evolution.

20 citations

protein structuredeep learning

𝕏 PostBluesky