Jeyun Jo

This study develops a covalent probe for imaging S. aureus biofilms in vitro and in vivo, showing high specificity for the serine hydrolase FphE.

The paper characterizes the structural and ligand-binding properties of Staphylococcus aureus FphE, revealing its unique dimeric structure and substrate engagement mechanisms.

The paper develops fluorescent probes for FphB, a Staphylococcus aureus enzyme, using mRNA display with a genetically encoded electrophile, achieving nanomolar selectivity.

The paper develops oxadiazolone-based probes targeting FphE to specifically detect S. aureus infections through covalent modification of the enzyme's active site.