Keisuke Ito

The paper identifies a vagal sensory pathway activated by intestinal fructose that does not suppress food intake, unlike glucose, potentially contributing to overconsumption of fructose.

This study shows that aberrant oxidative metabolism drives the selection of TET2-deficient hematopoietic stem and progenitor cells in clonal hematopoiesis, with the pentose phosphate pathway playing a compensatory role.

This paper shows that targeting STAT3 with a degrader can overcome Venetoclax resistance in AML by reducing MCL1 and improving mitochondrial function.

The paper shows that elevated endocytic trafficking via GPRASP2 maintains HSC quiescence and prevents functional exhaustion.

The paper identifies non-coding variants associated with clonal hematopoiesis and demonstrates their regulatory impact on gene expression and clonal expansion.

This study shows that LDHA is essential for maintaining NAD+/NADH balance in AML cells, and its inhibition leads to cell death, suggesting it as a therapeutic target.

This paper develops a deep learning algorithm to infer uterine contractions from maternal ECGs, achieving a Pearson correlation coefficient of 0.53 with ground truth data.