Gil Wiseglass

This study shows VISTA interacts with its ligands in cis, not trans, due to its membrane orientation, and finds a correlation between VISTA and PSGL-1 in cancer data.

The paper shows that cis-interactions of clustered protocadherins are essential for combinatorial cell-cell recognition, and mismatched isoforms disrupt trans complex stability, leading to neuronal self-avoidance.

This study investigates how Dscam1 proteins evolved strict homophilic specificity through evolutionary intermediates that allowed promiscuous interactions.