Cancer BiologybioRxivPreprint
SUMO Inhibition Plus CD40 Agonism Increases Anti-Tumor Immunogenicity Through Interferon Mediated Macrophage Activation
Kevin Li, Asimina S. Courelli, James Lee…·Andrew M. Lowy
This study shows that combining SUMO inhibition with CD40 agonism enhances anti-tumor immunogenicity in PDAC by improving macrophage function and T-cell infiltration, leading to improved survival in a mouse model.
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