Kenneth Yee Tsai

This study identifies three phases of UV-induced skin carcinogenesis using a mouse model, showing the emergence of large clades, clonal selection, and lesion formation.

This study identifies MAFG as a driver of melanoma progression by interacting with MITF to alter gene expression and promote a dedifferentiated melanoma phenotype.

This study develops an endogenous lung cancer model in naked mole-rats, showing tumor initiation more closely resembles human tumors than in mice.

The paper uses spatial transcriptomics to identify increased spatial coupling of integrin and collagen IV in immunoresistant clear cell renal cell carcinoma tumors, suggesting integrin as a therapeutic target.

This study identifies PHGDH induction via MAPK and mTORC1 pathways as essential for melanoma formation and shows that combining BRAFV600E inhibition with serine restriction can target this vulnerability.

The paper reports that sun exposure induces pervasive mutations at UV-sensitive RNA-processing gene promoters, with clonal expansion observed in both tumor suppressor gene hotspots and CPD hyperhotspots.

spatialGE simplifies spatial transcriptomics analysis by providing a user-friendly web interface for non-programmers, enabling tasks like quality control, domain detection, and spatial analysis.

This study uses spatial transcriptomics to identify a tumor-promoting role of meningeal stroma in melanoma leptomeningeal disease and shows that targeting SERPINA3 or its downstream pathway can restore drug sensitivity.

This study evaluates the therapeutic potential of RMC-7977, a broad-spectrum RAS inhibitor, in pancreatic ductal adenocarcinoma models, showing strong anti-tumor effects with minimal impact on normal tissues.

The paper introduces spatialGE, a software tool for quantifying and visualizing tumor microenvironment heterogeneity using spatial transcriptomics data.