Michalis Averof

The paper investigates chromatin state reorganization during leg regeneration in pancrustaceans, finding a conserved sequence of chromatin resetting and pioneer factor activation across species.

The paper develops resources to identify cis-regulatory elements in the Parhyale hawaiensis genome using ATAC-seq and sequence conservation analysis.

The paper develops a toolkit of membrane-localising tags tested across ten animal species to identify effective signals for targeting proteins to the plasma membrane.

The paper presents a method for long-term live imaging and cell tracking during crustacean leg regeneration, enabling detailed analysis of cell fates and lineages.

The paper shows that regenerated crustacean legs in Parhyale precisely replicate the microanatomy, sensory function, and transcriptional profiles of uninjured legs.

This study compares gene expression dynamics during leg development and regeneration in Parhyale hawaiensis, finding distinct temporal patterns despite shared gene sets.

ELEPHANT enables accurate 3D cell lineage tracking in crustacean leg regeneration using an incremental deep learning approach with minimal user effort.

CeLaVi is a web-based tool for visualizing and interacting with cell lineages, integrating spatial distribution and cell properties.

This study uses simulations to evaluate the accuracy of CRISPR-based lineage reconstruction under various biological and technical conditions.

The paper introduces Valcyrie, a CRISPR-based method for tunable clonal marking in Tribolium castaneum, enabling controlled clone induction frequency.

The paper identifies a conserved gene regulatory module co-opted multiple times for the evolution of flat structures in arthropods.

The paper sequences and annotates the genome of Parhyale hawaiensis, identifying key genes for development, immunity, and lignocellulose digestion, providing a resource for comparative studies.