Jon D. Lane

The paper identifies ER-liquid condensates that sequester FAM134B/C and RhoA, affecting cell morphology and cancer invasion.

This study shows that loss of lmx1ba in zebrafish causes premature osteoarthritis by disrupting skeletal homeostasis and joint maintenance in adult life.

The paper characterizes lmx1b paralogues in zebrafish, revealing distinct roles in skeletal, kidney, and muscle development, and identifies a new role in notochord cell inflation.

This study shows that autophagy is essential for proper chondrocyte maturation and joint formation in zebrafish, with its disruption causing premature hypertrophy and developmental defects.

This study evaluates the effectiveness of different CRISPR effectors for targeting mitochondria, finding that LbCas12a shows better targeting and tolerance than Cas9 variants.

This study shows LMX1A and LMX1B regulate autophagy in human midbrain dopaminergic neurons through LIR interactions, affecting mitochondrial function and resilience to rotenone toxicity.