Gilles Charvin

The paper shows that mitochondrial dysfunction in budding yeast mimics aging by causing a state with low membrane potential and heme loss, affecting both young and old cells.

The paper identifies a threshold telomere length in telomerase-negative cells that triggers replicative senescence and genomic instability through dysfunction of the shortest telomere.

This study identifies a novel feedback system regulating Cdk function through Spo12, a small disordered protein that inhibits PP2A, and shows its role in enhancing cell proliferation in fission yeast.

COSPLAY provides a modular, expandable toolbox for generating yeast expression plasmids using a Golden Gate approach and software-assisted protocol.

This study shows that nucleolar stress from ERC accumulation causes replicative senescence in budding yeast, but not in long-lived fob1{triangleup} mutant cells.