Yale S. Michaels

This study shows how to generate CD4+ T cells from pluripotent stem cells by controlling Notch and T cell receptor signaling, enabling clonally diverse and expandable cells that can differentiate into helper cell types.

The paper introduces UNMASC, a mathematical model to analyze non-monotonic cytokine interactions in T cell differentiation, showing synergistic and antagonistic effects in cytokine combinations.

This study creates a single-cell multiomics atlas of B cell development in prenatal and adult bone marrow and in vitro models, identifying novel cell subsets and molecular signatures.

This study shows that varying CAR expression levels in T cells affects their activation, function, and transcriptional identity, with optimal CAR levels preventing exhaustion.

This study uses time-resolved single-cell RNA sequencing to uncover gene expression programs and clonal relationships during human T lineage specification.

The paper develops synthetic gene circuits in human pluripotent stem cells that convert discrete cell states into analog signals by integrating miRNAs with miSFITs for controlled effector protein production.

This paper introduces miSFITs, synthetic microRNA response elements that allow precise control of gene expression levels in mammalian cells, showing their utility in modulating antigen expression in a mouse melanoma model.