Peter W. Zandstra

This study shows how mechanical forces and substrate properties enhance T-cell receptor proofreading by delaying decision-making and improving ligand discrimination.

The paper shows that gene syntax influences supercoiling-mediated transcriptional feedback, affecting adjacent gene expression in human cells.

This study shows how to generate CD4+ T cells from pluripotent stem cells by controlling Notch and T cell receptor signaling, enabling clonally diverse and expandable cells that can differentiate into helper cell types.

The paper develops a framework to predict and control collective fate in multicellular systems by identifying a control regime where a single guide cell can redirect tissue-level organization.

This study creates a single-cell multiomics atlas of B cell development in prenatal and adult bone marrow and in vitro models, identifying novel cell subsets and molecular signatures.

This study uses time-resolved single-cell RNA sequencing to uncover gene expression programs and clonal relationships during human T lineage specification.

This study identifies distinct gene regulatory networks in hematopoietic stem cells and leukemia stem cells using integrated gene expression and chromatin accessibility data from AML patients and human umbilical cord blood.

This study uses human naive PSC models to show FGF signaling is critical for hypoblast specification, revealing conservation with mouse lineage specification.

The paper uses a computational model and experiments to show that small micro-patterned mPSC colonies exhibit spontaneous asymmetry in BRA-GFP patterns, suggesting a mechanism for symmetry-breaking in development.

The paper develops a GRN model embedded in cellular agents to simulate hPSC lineage commitment and shows how GRN wiring influences germ layer pattern formation.

IQCELL predicts gene perturbation effects on developmental trajectories using scRNA-seq data, showing it can infer over 75% of known causal gene interactions in mouse T-cell development.

The paper develops synthetic gene circuits in human pluripotent stem cells that convert discrete cell states into analog signals by integrating miRNAs with miSFITs for controlled effector protein production.

This paper shows nicotinamide promotes pancreatic endocrine progenitor differentiation via PARP inhibition, increasing Nkx6.1 and NAD+/NADH ratio.

The paper develops an in vitro platform to study fate patterning in hPSCs, revealing Nodal-dependent switches between gastrulation and neurulation-associated gene profiles.

The paper develops a computational model using Boolean logic to predict pluripotent stem cell fate transitions in response to signaling inputs.

The paper develops a high-throughput assay to study peri-gastrulation-like fate patterning in human pluripotent stem cells, revealing coordination between Reaction-Diffusion and Positional-Information mechanisms.