MicrobiologyJournal of Clinical InvestigationPeer-reviewed
Macrophage-intrinsic MDA5-IRF5 axis drives HIV-1 icRNA-induced inflammatory responses
Sita Ramaswamy, Hisashi Akiyama, Jacob L. Berrigan…·Suryaram Gummuluru
This study identifies the MDA5-IRF5 axis as critical for HIV-1 icRNA-induced inflammatory responses in macrophages, with IRF5 mediating enhanced IP-10 expression in older individuals.
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