PhysiologyHypertensionPeer-reviewed
Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Aortic Stiffening: Role of Glycation Stress
Ravinandan Venkatasubramanian, Mary Darrah, Sophia A. Mahoney…·Zachary Stephen Clayton
This study shows that doxorubicin chemotherapy induces aortic stiffening via cellular senescence and the senescence-associated secretory phenotype, which can be mitigated by senolytic therapy.
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