Peter R. Arvan

This study identifies SEL1L-HRD1 ERAD as a regulator of PC2 maturation and glucagon production in islet α cells by degrading misfolded proPC2.

This study identifies two small molecule inhibitors of FICD that suppress both endogenous and pathologic protein AMPylation, improving proinsulin processing in β cells.

This study shows chronic ER stress induces β-cell plasticity, but excessive stress leads to identity loss and is linked to T1D progression.

This paper develops a mouse model with an epitope-tagged BiP/GRP78 protein to study its interactome and role in ER protein misfolding in vivo.

This study identifies TRAP as essential for insulin biogenesis, showing it facilitates preproinsulin translocation and affects downstream processing and secretion.

The paper identifies a Redox Thiol Switch (RTSGS) that regulates cellular energy metabolism by switching between S-glutathionylation and S-sulfhydration, with PCK2 as a novel target.