Gut archaea drive human MAIT cell responses
Natasha Fisher-Pearson, Martin Joseph Lett, Isaac W. D. Maylam…·Jethro S. Johnson
The paper shows that gut archaea produce 5-OP-RU, which activates MAIT cells, linking archaea to human immunity.
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Immunocore (United Kingdom)ORCID 0000-0002-6962-6533Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Natasha Fisher-Pearson, Martin Joseph Lett, Isaac W. D. Maylam…·Jethro S. Johnson
The paper shows that gut archaea produce 5-OP-RU, which activates MAIT cells, linking archaea to human immunity.
Daniel J. Burns, Alex Look, Steven Turner…·Salah Mansour
This study determines the crystal structures of human and macaque CD1d bound to -GalCer, revealing conserved ligand-responsive conformational flexibility at Phe84 that modulates antigen presentation.
Torcato Martins, Yao Meng, Bogusława Korona…·Sarah J. Bray
The paper shows that the Delta C2 domain β1-2 loop is essential for phospholipid binding and robust Notch signaling in Drosophila.