Joshua David Schiffman

This study identifies 14 susceptibility loci for Ewing sarcoma through a genome-wide association meta-analysis, revealing genetic interactions with somatic EWSR1::FLI1 fusions.

The paper analyzes immune-cancer tradeoffs across mammals, finding a negative correlation between cancer and trauma mortality, mediated by platelet size and trophic level.

This study identifies neutrophil extracellular traps (NETs) as a contributor to EEHV-HD pathogenesis and demonstrates their inhibition as a potential therapeutic strategy.

The paper finds a positive correlation between germline mutation rates and cancer mortality across 37 vertebrate species.

This study identifies inherited pathogenic variants in DNA damage repair genes as a distinct germline risk factor for Ewing sarcoma, with FANCC showing significant enrichment.

The paper establishes variant filtering guidelines for rare disease studies and estimates candidate variant yields for different inheritance modes using slivar software.

The paper constructs a mathematical model of ATM and ATR crosstalk in response to DNA damage, showing how crosstalk mechanisms influence pro-apoptotic signaling.