Author

Charles H. Graham

Queen's UniversityORCID 0000-0002-7014-8639Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Cancer Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Andrew W. CraigiD· 3 shared Peter A. GreeriD· 3 shared Richard W. NaumaniD· 3 shared Tiziana CotechiniiD· 3 shared Amber L. SimpsoniD· 2 shared Andrew GarveniD· 2 shared D. Robert SiemensiD· 2 shared David Monty BermaniD· 2 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Andrew W. CraigORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

ImmunologyPLoS ONEPeer-reviewedSep 11, 2026

Differential effects of BCG-Russia and BCG-TICE on trained immunity: potential implications for bladder cancer immunotherapy

Richard W. Nauman, Peter A. Greer, Andrew W. Craig…·Charles H. Graham

This study compares the effects of BCG-Russia and BCG-TICE on trained immunity in mice, finding BCG-TICE induces stronger innate immune memory and inflammation-related gene expression.

DOI 10.1371/journal.pone.0357950

mouseproteomics

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Cancer BiologybioRxivPreprintMay 10, 2026

Failure of Bacillus Calmette-Guerin Therapy in Patients with Bladder Cancer is Characterized by Immune Dysfunction Associated with Activator Protein 1

Andrew Garven, Jean‐François Paré, Alexandra Robins…·Charles H. Graham

This study identifies immune dysfunction linked to AP-1 in BCG non-responders with NMIBC, suggesting pre-existing immunosenescence contributes to early recurrence.

DOI 10.64898/2026.05.06.723215

humanscRNA-seq

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ImmunologyCancer ResearchPeer-reviewedApr 29, 2025

Fes-deficient macrophages enhance CD8+ T cell priming and tumour control through increased proinflammatory cytokine production and localization

Brian J. Laight, Danielle Harper, Natasha Dmytryk…·Peter A. Greer

3 citations

mousebulk RNA-seq

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Developmental BiologybioRxivPreprintNov 9, 2021

Transgenerational impact of aberrant inflammation in rat pregnancy

Takafumi Ushida, Tiziana Cotechini, Nicole Protopapas…·Charles H. Graham

This study shows that maternal inflammation during pregnancy can lead to transgenerational risks of cardiovascular and metabolic diseases in offspring.

DOI 10.1101/2021.11.09.467505

ratexperimental assay

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