Didier Surdez

The paper develops a 3D culture platform for Ewing sarcoma and identifies a synergy between statins and BCL-xL inhibitors targeting the mevalonate pathway.

Chiron3D predicts CTCF-mediated chromatin loops using a DNA-only model, revealing sequence determinants of loop strength and stability through interpretable deep learning.

The paper introduces a PDX platform for pediatric cancers, providing in vivo drug testing models and molecular data to aid in therapy development.

Mechanical overload activates hypoxia-inducible factor 1-alpha (HIF1a) in tenocytes to drive tendinopathy independently of VEGFA-mediated vascular ingrowth, and tenocyte Hif1a deletion prevents overload-induced tendon degeneration in mice.

This study shows that reduced EWSR1::ETS activity in Ewing sarcoma promotes immune evasion via the tryptophan-kynurenine-AHR axis, leading to worse clinical outcomes and tumor progression.

This study compares genomic and phenotypic stability of pediatric Ewing sarcoma cell lines to adult carcinoma cell lines over 12 months of culture.

The paper presents a multi-omics cell line atlas for Ewing sarcoma, identifying new target genes and regulatory mechanisms of EWSR1-ETS fusion oncogenes.