Juan R. Alvarez‐Dominguez

This study shows DEC1 regulates β cell maturation and circadian rhythm in stem cell-derived islets, improving their functional maturity and glucose responsiveness.

Agentic Lab integrates AI agents with physical lab operations to improve reproducibility in cell and organoid research by autonomously generating protocols and analyzing experimental data.

The paper introduces STAgent, an AI tool that automates spatial transcriptomics analysis, revealing in vivo maturation of human stem cell-derived pancreatic cells.

The paper uses flexible electronics to study electrical maturation of human pancreatic islets over time, identifying key electrical states and their role in hormone secretion.

This paper identifies translation inhibitors that enable ex vivo expansion of human hematopoietic stem cells from umbilical cord blood while maintaining their function and enabling gene editing.

This study profiles the epigenome during human islet differentiation, revealing epigenetic priming of lineage-defining loci and the role of LMX1B in endocrine progenitor regulation.