Cell BiologybioRxivPreprint
Induced ubiquitination bypasses canonical ERAD to drive ER protein degradation
Sydney J. Tomlinson, Sean L. Johnson, Anna H. Kroskrity…·James A. Olzmann
This paper demonstrates that ER membrane proteins can be degraded via cytosolic E3 ligase recruitment, bypassing ERAD and relying on VCP-mediated ubiquitin chain cleavage.
DOI 10.1101/2025.11.28.691080