Author

Philip V Seegren

Howard Hughes Medical InstituteORCID 0000-0002-7153-4670Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Amir RattneriD· 1 shared Jeremy NathansiD· 1 shared Philip M. Smallwood· 1 shared Yanshu WangiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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1 shared paperImmunology

Amir RattnerORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintAug 21, 2026

Defining a leptomeningeal blood cerebrospinal fluid barrier as a specialized vascular interface

Philip V. Seegren

The paper identifies leptomeningeal endothelial cells as a distinct vascular population with unique molecular and functional properties compared to cortical blood brain barrier endothelial cells.

DOI 10.64898/2026.08.19.745529

humanbulk RNA-seq

𝕏 PostBluesky

ImmunologyeLifePeer-reviewedAug 7, 2026

TLR4 signaling drives tissue inflammation, Claudin-5 internalization,and vascular barrier breakdown in a mouse model of neonatal meningitis

Philip V Seegren, Amir Rattner, Philip M. Smallwood…·Jeremy Nathans

DOI 10.7554/elife.110458.4

mousebulk RNA-seq

𝕏 PostBluesky