Larry S. Schlesinger

This study identifies DUSP1 as a regulator of inflammatory and mitochondrial responses in macrophages exposed to Borrelia burgdorferi lipoproteins, with implications for therapeutic targeting.

This paper develops an agent-based model to simulate immune responses to Mycobacterium tuberculosis infection, showing that early macrophage-CD4+ T cell interactions in latent TB infection reduce bacterial load through TNF and IFNγ mechanisms.

This study shows that elderly lung mucosa alters Mycobacterium tuberculosis gene expression, enhancing its metabolic adaptation and survival in alveolar epithelial cells.

The paper examines inter-individual variability in human alveolar macrophage responses to Mycobacterium tuberculosis by analyzing gene and protein expression over time.

This study shows that Mycobacterium tuberculosis alters its cell envelope gene expression in response to human alveolar lining fluid, with differences observed between young and elderly donors.

This study identifies neutrophils in elderly lungs as contributors to a dysregulated environment, providing a proteomic baseline for future research on respiratory infection susceptibility.