ImmunologyFrontiers in ImmunologyPeer-reviewed
5,6-dimethylxanthenone-4-acetic acid (DMXAA), a Partial STING Agonist, Competes for Human STING Activation
Burcu Temizoz, Takayuki Shibahara, Kou Hioki…·Ken J. Ishii
This paper investigates DMXAA's partial STING agonist activity and develops HHMX, a derivative that antagonizes STING-mediated immune responses in both humans and mice.