Masahiro Yamamoto

The paper identifies MIC11 as an essential gene for Toxoplasma gondii egress, showing it interacts with PLP1 to disrupt host cell membranes.

This study identifies Gelsolin as a regulator of ER stress in psoriasis-like dermatitis, showing it counteracts inflammatory circuits driven by IMQ-induced organelle stress.

This study identifies cardiolipin as a selective inhibitor of caspase 4/11 that prevents LPS-induced inflammation without affecting caspase-1, offering a potential therapeutic for Gram-negative sepsis.

The paper uses in vivo CRISPR screens to identify virulence genes among Toxoplasma proteins with unassigned subcellular localizations, finding two essential genes conserved in Apicomplexa.

This paper investigates DMXAA's partial STING agonist activity and develops HHMX, a derivative that antagonizes STING-mediated immune responses in both humans and mice.