Marc G. Chevrette

The paper integrates genome mining and structure-guided modeling to discover new 7-deazapurine-containing biosynthetic gene clusters and their chemical functions.

Random forest predictors PARAS and PARASECT, trained on 3,653 curated adenylation domains, outperform earlier NRPS substrate predictors and correctly assigned L-Trp to an unusual tryptopeptin synthetase domain.

The paper introduces a collaborative platform for curating microbial metabolite knowledge to enhance metabolomics data interpretation.

This study identifies labradorin 1, an indole compound from Pseudomonas sp. TE4607, as a nematicidal agent effective against both free-living and parasitic nematodes.

This paper predicts microbial metabolic interactions using cross-species co-expression analysis of RNA-sequencing data from microbiome datasets.

The paper investigates how snake skin lipid chemistry and the microbiome influence the growth of Ophidiomyces ophidiicola, revealing antifungal lipids and bacterial-fungal interactions that shape the skin microbiome.

The paper introduces GATOR-GC, a genome mining tool that identifies diverse gene clusters and maps their evolutionary patterns, revealing previously uncharacterized biosynthetic functions.

This paper introduces a whole bacterial proteome foundation model trained on ESM embeddings to capture gene interactions and genomic integrity, achieving state-of-the-art results in operon identification and genotype-phenotype mapping.

This study identifies the biosynthesis of triculamin, a lasso peptide with antimycobacterial activity, and shows its convergent evolution across bacterial phyla.

This study identifies genes in Flavobacterium johnsoniae critical for surface colonization in both solitary and community settings using a model microbial community.

The paper introduces the Natural Products Discovery Center, releasing 8490 sequenced Actinobacteria strains and highlighting their taxonomic and biosynthetic diversity.

The paper identifies and characterizes constitutive promoters across three Proteobacteria classes, showing their expression range and portability between hosts.

The paper analyzes genetic diversity and biosynthetic potential in Pseudonocardia bacteria associated with fungus-growing ants across a 20km transect, revealing geographic and phylogenetic patterns of microbial diversity.