Ana Crespillo-Casado

This study shows Shigella flexneri uses IpaH1.4 to degrade RNF213 and prevent LPS ubiquitylation, evading host antibacterial autophagy.

This study identifies how RNF213 recognizes diverse pathogens through enzymatic amplification of cooperative recruitment.

The paper identifies an ISRIB-binding site in eIF2B using cryo-EM and CRISPR/Cas9, showing its role in regulating translation through an allosteric mechanism.