Author

Alisa F. Zyryanova

University of CambridgeORCID 0000-0002-9885-6012Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Approach:mechanistic / dynamical model· 1 Assay:proteomics· 1

Frequent Co-Authors

David RoniD· 3 shared Heather P. HardingiD· 3 shared Ginto GeorgeiD· 2 shared Akeel Abo AlardiD· 1 shared Alan John WarreniD· 1 shared Alexandre FailleiD· 1 shared Amirhossein MafiiD· 1 shared Ana Crespillo-CasadoiD· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMolecular Biology

David RonORCID

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3 papers

Recent·Most cited

Molecular BiologyNature CommunicationsPeer-reviewedMay 6, 2026

A molecular stabiliser of an inhibitory eIF2B-eIF2(αP) complex activates the Integrated Stress Response

Fiona Shilliday, Miguel Gancedo-Rodrigo, Ginto George…·John E. Linley

The paper identifies a chemical inhibitor of eIF2B that activates the Integrated Stress Response by stabilizing an inhibitory complex with phosphorylated eIF2.

1 citation

experimental assay

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BiochemistryProceedings of the National Academy of SciencesPeer-reviewedMar 28, 2024

Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the Integrated Stress Response

Yahui Yan, Maithili Shetty, Heather P. Harding…·David Ron

The paper identifies a mechanism by which eIF2γ binding to PPP1R15A enhances catalytic efficiency of the holophosphatase that terminates the integrated stress response.

7 citations

humanproteomics

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Molecular BiologybioRxivPreprintNov 25, 2017

Binding of the integrated stress response inhibitor, ISRIB, reveals a regulatory site in the nucleotide exchange factor, eIF2B

Alisa F. Zyryanova, Félix Weis, Alexandre Faille…·David Ron

The paper identifies an ISRIB-binding site in eIF2B using cryo-EM and CRISPR/Cas9, showing its role in regulating translation through an allosteric mechanism.

1 citation

humanexperimental assay

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