Hsuan Pai

This study identifies tissue-specific NLR expression patterns across legume species using phylogenomics and transcriptomics.

The paper shows that the rice NLR pair Pik-1 and Pik-2 forms a hetero-oligomeric complex at the plasma membrane in the resting state before effector activation.

The study shows that autoactive mutants of tomato NRC proteins still induce cell death in prf mutants and in lettuce, indicating a unidirectional dependency in the NRC immune network.

This paper identifies an effector from Phytophthora infestans that bridges NbTOL9a to an activated NLR to suppress immunity, revealing a novel structural and functional mechanism.

The paper identifies a root-specific NLR gene cluster in tomato that confers resistance to nematodes and evolved from an ancient NRC network.

The paper shows that NRC3 evolved to resist suppression by a nematode effector, revealing a new type of gene-for-gene interaction between pathogens and host immune receptors.

The paper analyzes NLR evolution in lettuce and related species, finding that sensor NLRs evolve faster than helper NLRs and that sensor diversification is linked to helper dependency.

This study shows how the helper NLR NRC2 converts from a homodimer to a higher-order oligomer upon activation by the sensor NLR Rx, revealing the molecular mechanism of plant immune activation.