Chih‐Hang Wu

The paper investigates the evolution of NRC helper NLRs across Solanaceae, identifying conserved core and dynamic periphery subfamilies and their functional rewiring.

This study shows how a plant pathogen effector blocks the stepwise assembly of a helper NLR resistosome by stabilizing an intermediate state.

This study identifies NRG1 as a plant NLR receptor that targets chloroplasts to trigger immunity by channeling stromal calcium into the cytosol, revealing a novel mechanism for organelle-specific immune signaling.

The study identifies a hydrophobic core in the coiled-coil domain of NRCs that is essential for their function in immunity.

This study enhances Agrobacterium-mediated genome editing in Arabidopsis by optimizing floral stages and engineering Agrobacterium to evade plant immunity, achieving high transformation efficiency without antibiotic selection.

The study shows that autoactive mutants of tomato NRC proteins still induce cell death in prf mutants and in lettuce, indicating a unidirectional dependency in the NRC immune network.

This paper compares transcriptomic responses of Agrobacterium strains under in vitro and in planta conditions, revealing strain-specific and context-dependent gene regulation during plant colonization.

BaMV infection enhances mitochondrial metabolism to regulate cytoplasmic redox balance and promote antiviral defense.

The paper visualizes calcium signaling and organelle dynamics during resistosome-mediated cell death in plants, revealing a sequential cascade of subcellular events.

The paper identifies a root-specific NLR gene cluster in tomato that confers resistance to nematodes and evolved from an ancient NRC network.

This paper shows that Rhizobium rhizogenes A4-derived strains provide more efficient transient gene expression in Nicotiana benthamiana and other solanaceous plants compared to common agrobacterial strains.

This study shows how the helper NLR NRC2 converts from a homodimer to a higher-order oligomer upon activation by the sensor NLR Rx, revealing the molecular mechanism of plant immune activation.

The paper shows how functional divergence in NRC3 variants shapes the genetic architecture of the NLR network in solanaceous plants, leading to subfunctionalization and increased immune system complexity.

This paper develops a copper-inducible gene expression system in Nicotiana benthamiana to tightly regulate transgene expression and cell death assays.

The paper investigates the evolution of NRC immune receptor networks across plant lineages, finding significant expansion and complexity in lamiids compared to Ericales and campanulids.

The paper investigates the functional conservation of the NRC0 gene cluster across asterid plants and shows its role in immune responses.