ImmunologyEMBO Molecular MedicinePeer-reviewed
Scarring hair follicle destruction is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege
Karoline Strobl, Jörg Klufa, Regina Jin…·Thomas Bauer
This study shows that EGFR protects hair follicle stem cells from immune-mediated damage by maintaining JAK-STAT1-sensitive immune privilege, and its disruption leads to scarring hair loss, which can be reversed by JAK1/2 inhibition.